Design and Synthesis of .ALPHA.-Glucosidase Inhibitor Having DNA Cleaving Activity
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چکیده
منابع مشابه
Design and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...
متن کاملDesign and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...
متن کاملDesign, Synthesis, and Biological Evaluation of novel Alpha Glucosidase Inhibitors
To develop a lead anti-diabetic compound, a series of 21 novel quinazoline derivatives have been synthesized and screened against alpha Glucosidase. The binding mode of the compounds at the active site of alpha Glucosidase was explored using Glide docking method. The binding model suggests one to four hydrogen bonding interactions between quinazoline derivatives and alpha-glucosidase. 6-Bromo-2...
متن کاملVoglibose: An Alpha Glucosidase Inhibitor
keywords: Postprandial hyperglycaemia (PPHG), Alpha glucosidase inhibitors (αGI) ABSTRACT Diabetes Mellitus (DM) is a morbid disease worldwide, with increasing incidence as time passes. It has macro-vascular and micro-vascular complications. The main cause of these complications is poorly controlled postprandial hyperglycaemia. Alpha glucosidase inhibitors, namely acarbose, voglibose and miglit...
متن کاملdesign and synthesis of new benzimidazole and pyrimidine derivatives as α-glucosidase inhibitor
in an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (pocl3). the synthesized compounds were identified by 1h-nmr, 13c-nmr, ft-ir spectroscopic techniques and elemental analysis. all products were...
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ژورنال
عنوان ژورنال: Journal of Applied Glycoscience
سال: 2006
ISSN: 1344-7882,1880-7291
DOI: 10.5458/jag.53.255